The intraflagellar transport machinery in ciliary signaling

Mourao, Andre; Christensen, Soren T.; Lorentzen, Esben

doi:10.1016/j.sbi.2016.06.009

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The intraflagellar transport machinery in ciliary signaling

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Mourao, Andre
Lorentzen, Esben / Intraflagellar Transport, Max Planck Institute of Biochemistry, Max Planck Society;

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Lorentzen, Esben
Lorentzen, Esben / Intraflagellar Transport, Max Planck Institute of Biochemistry, Max Planck Society;

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Mourao, A., Christensen, S. T., & Lorentzen, E. (2016). The intraflagellar transport machinery in ciliary signaling. Current Opinion in Structural Biology, 41, 98-108. doi:10.1016/j.sbi.2016.06.009.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-F18D-B

Abstract

Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-beta, Wnt, PDGFR alpha, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.