English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.

MPS-Authors
/persons/resource/persons15029

Eibl,  H. J.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

2404133.pdf
(Publisher version), 307KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Vehmeyer, K., Kim, D. J., Nagel, G., Eibl, H. J., & Unger, C. (1989). Effect of ether lipids on mouse granulocyte-macrophage progenitor cells. Cancer Chemotherapy and Pharmacology, 24(1), 58-60. doi:10.1007/BF00254107.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-9154-7
Abstract
In this study we determined the potential bone marrow toxicity of the ether lipid derivatives 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (OcMe-G-3-PC), 1-0-hexadecyl-propanediol-2-phosphocholine (He-Pr-2-PC), and hexadecylphosphocholine (He-PC). OcMe-G-3-PC inhibited the proliferation of mouse granulocytemacrophage progenitor cells (GM-CFCs) at a dose of 1 μg/ml, whereas He-Pr-2-PC and He-PC started to inhibit the growth of hemopoietic precursors at 5 μg/ml. In contrast to this finding, NMRI mice given 10 mg/kg i.v. daily for 4 weeks and 20 or 30 mg/kg for 5 days showed no bone marrow toxicity. We conclude that the dose-dependent toxic effects observed in vitro are within the physiological tolerance in vivo.