English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex

MPS-Authors
/persons/resource/persons195482

Huntenburg,  Julia M.
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Education and Psychology, FU Berlin, Germany;

/persons/resource/persons23475

Bazin,  Pierre-Louis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons49466

Tardif,  Christine
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada;

/persons/resource/persons20065

Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19840

Margulies,  Daniel S.
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Huntenburg, J. M., Bazin, P.-L., Goulas, A., Tardif, C., Villringer, A., & Margulies, D. S. (2017). A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex. Cerebral Cortex, 27(2), 981-997. doi:10.1093/cercor/bhx030.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-886F-C
Abstract
Research in the macaque monkey suggests that cortical areas with similar microstructure are more likely to be connected. Here, we examine this link in the human cerebral cortex using 2 magnetic resonance imaging (MRI) measures: quantitative T1 maps, which are sensitive to intracortical myelin content and provide an in vivo proxy for cortical microstructure, and resting-state functional connectivity. Using ultrahigh-resolution MRI at 7 T and dedicated image processing tools, we demonstrate a systematic relationship between T1-based intracortical myelin content and functional connectivity. This effect is independent of the proximity of areas. We employ nonlinear dimensionality reduction to characterize connectivity components and identify specific aspects of functional connectivity that are linked to myelin content. Our results reveal a consistent spatial pattern throughout different analytic approaches. While functional connectivity and myelin content are closely linked in unimodal areas, the correspondence is lower in transmodal areas, especially in posteromedial cortex and the angular gyrus. Our findings are in agreement with comprehensive reports linking histologically assessed microstructure and connectivity in different mammalian species and extend them to the human cerebral cortex in vivo.