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Independent natural genetic variation of punishment- versus relief-memory

MPG-Autoren
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Appel,  Mirjam
Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society;

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Kocabey,  Samet
Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society;

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Savage,  Sinead
Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society;

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Yarali,  Ayse
Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society;

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rsbl20160657supp2.xlsx
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Zitation

Appel, M., Scholz, C.-J., Kocabey, S., Savage, S., Koenig, C., & Yarali, A. (2016). Independent natural genetic variation of punishment- versus relief-memory. Biology Letters, 12(12): 20160657. doi:10.1098/rsbl.2016.0657.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002C-6459-F
Zusammenfassung
A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment-versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment-and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.