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New loci for body fat percentage reveal link between adiposity and cardiometabilic disease risk

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Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Lu, Y., Day, F. R., […], [., & Loos, R. J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabilic disease risk. Nature Communications, 7, 10495-10495. doi:10.1038/ncomms10495.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-AFA0-C
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.