Influence of the red blood cell Ca2+-ion concentration on the erythrocyte 
aggregation in stasis.

Friederichs, E.; Winkler, A. H.; Tillmann, W.

doi:10.1016/0885-4505(89)90013-3

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Influence of the red blood cell Ca2+-ion concentration on the erythrocyte aggregation in stasis.

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Winkler, A. H.
Abteilung Biochemische Kinetik, MPI for biophysical chemistry, Max Planck Society;

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Citation

Friederichs, E., Winkler, A. H., & Tillmann, W. (1989). Influence of the red blood cell Ca2+-ion concentration on the erythrocyte aggregation in stasis. Biochemical Medicine and Metabolic Biology, 41(2), 85-92. doi:10.1016/0885-4505(89)90013-3.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-4BFD-3

Abstract

Ca2+ ions were transported into the cell by incubation of the erythrocyte suspension with ionophore A23187, a lipophil electric neutral ion complexing substance. Erythrocyte aggregation could be increased twice, when doubling the intracellular Ca2+-ion concentration. Our measurements lead to the suggestion that an increase of the cytoplasmatic Ca2+ ion changes the physical and/or biochemical properties of the aggregation receptors on the membrane surface, i.e., cell-protein interactions are regulated by alteration of the intracellular Ca2+-ion concentration.