Further investigation on the high-conductance ion channel of the inner membrane 
of mitochondria.

Sorgato, M. C.; Moran, O.; De Pinto, V.; Keller, B. U.; Stühmer, W.

doi:10.1007/BF00762520

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Further investigation on the high-conductance ion channel of the inner membrane of mitochondria.

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Keller, B. U.
Research Group of Cellular Neurophysiology, MPI for biophysical chemistry, Max Planck Society;

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Stühmer, W.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Sorgato, M. C., Moran, O., De Pinto, V., Keller, B. U., & Stühmer, W. (1989). Further investigation on the high-conductance ion channel of the inner membrane of mitochondria. Journal of Bioenergetics and Biomembranes, 21(4), 485-496. doi:10.1007/BF00762520.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-3C65-1

Abstract

By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.