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Journal Article

Technique of surface modification of a cell-adhesion resistant hydrogel by a cell-adhesion-available inorganic microarray

MPS-Authors
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Graeter,  Stefan V.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons76135

Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

External Resource

http://pubs.acs.org/doi/pdf/10.1021/bm800477s
(Any fulltext)

http://pubs.acs.org/doi/suppl/10.1021/bm800477s
(Supplementary material)

https://doi.org/10.1021/bm800477s
(Any fulltext)

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Citation

Sun, J., Graeter, S. V., Yu, L., Duan, S., Spatz, J. P., & Ding, J. (2008). Technique of surface modification of a cell-adhesion resistant hydrogel by a cell-adhesion-available inorganic microarray. Biomacromolecules, 9(10), 2569-2572. doi:10.1021/bm800477s.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-414C-6
Abstract
A microtransfer technique for micropattern fabrication using a dithiol macromolecular linker is suggested by transferring a conventionally photolithography-prepared gold microarray on a hard inorganic substrate to a polymeric substrate. The linker was synthesized by end-capping a poly(ethylene glycol) (PEG) chain by the thiol groups. The efficiency of this technique is demonstrated by the transfer of gold microdots from glass to a cell-adhesion-resistant PEG hydrogel, which was formed by polymerizing PEG diacrylate macromers. The stability and biocompatibility of the resulting polymeric-inorganic hybrid material and cell-adhesion contrast of the patterned surface is confirmed by preliminary cell experiments.