Nanoparticle-based protein detection by optical shift of a resonant microcavity

Santiago-Cordoba, Miguel A.; Boriskina, Svetlana V.; Vollmer, Frank; Demirel, Melik C.

doi:10.1063/1.3599706

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Nanoparticle-based protein detection by optical shift of a resonant microcavity

MPS-Authors

/persons/resource/persons201226

Vollmer, Frank
Vollmer Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Santiago-Cordoba, M. A., Boriskina, S. V., Vollmer, F., & Demirel, M. C. (2011). Nanoparticle-based protein detection by optical shift of a resonant microcavity. APPLIED PHYSICS LETTERS, 99(7): 073701. doi:10.1063/1.3599706.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-69A1-F

Abstract

We demonstrated a biosensing approach which, for the first time, combines the high sensitivity of whispering gallery modes (WGMs) with a metallic nanoparticle-based assay. We provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection. We quantitatively analyzed the binding of a model protein (i.e., Bovine Serum Albumin) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model. (C) 2011 American Institute of Physics. [doi:10.1063/1.3599706]