Molecular tweezers target a protein–protein interface and thereby modulate 
complex formation

Trusch, F.; Kowski, K.; Bravo-Rodriguez, Kenny; Breuck, K.; Sowislok, A.; Wettig, B.; Matena, A.; Sanchez Garcia, Elsa; Meyer, H.; Schrader, T.; Bayer, P.

doi:10.1039/C6CC08039A

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Molecular tweezers target a protein–protein interface and thereby modulate complex formation

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Bravo-Rodriguez, Kenny
Research Group Sánchez-García, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Sanchez Garcia, Elsa
Research Group Sánchez-García, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Trusch, F., Kowski, K., Bravo-Rodriguez, K., Breuck, K., Sowislok, A., Wettig, B., et al. (2016). Molecular tweezers target a protein–protein interface and thereby modulate complex formation. Chemical Communications, 52(98), 14141-14144. doi:10.1039/C6CC08039A.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-11E1-0

Abstract

Molecular tweezers for lysine and arginine select a few residues on a protein surface and by their unique complexation mode disrupt a critical protein–protein interaction. Detailed structural information was gained by NMR experiments, strongly supported by QM/MM calculations and further substantiated by ITC, fluorescence anisotropy, ELISA and bio-layer-interference studies.