Epigenetic modulation of metabolic decisions

Öst, Anita; Pospisilik, John Andrew

doi:doi: 10.1016/j.ceb.2014.12.005

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Epigenetic modulation of metabolic decisions

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Pospisilik, John Andrew
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Öst, A., & Pospisilik, J. A. (2015). Epigenetic modulation of metabolic decisions. Current Opinion in Cell Biology, 33, 88-94. doi: doi: 10.1016/j.ceb.2014.12.005.

Cite as: https://hdl.handle.net/someHandle/test/escidoc:902580

Abstract

In the recent years there has been a tremendous increase in our understanding of chromatin, transcription and the importance of metabolites in their regulation. This review highlights what is currently sparse information that suggest existence of a refined system integrating metabolic and chromatin control. We indicate possible regulatory modes, such as feed forward amplification, that may help effect and stabilize long-lasting phenotypic decisions within and even across generations using adipogenesis as the primary context.