Modular C-H Functionalization Cascade of Aryl Iodides

Shi, Hang; Babinski, David J.; Ritter, Tobias

doi:10.1021/jacs.5b01082

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Modular C-H Functionalization Cascade of Aryl Iodides

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Ritter, Tobias
Harvard Univ, Dept Chem & Chem Biol;
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Shi, H., Babinski, D. J., & Ritter, T. (2015). Modular C-H Functionalization Cascade of Aryl Iodides. Journal of the American Chemical Society, 137(11), 3775-3778. doi:10.1021/jacs.5b01082.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-84C1-5

Abstract

We report the first example of ipsoborylation for the modular 1,2-bisfunctionalization of aryl iodides via C-H functionalization. The carbon-boron bond is used as a lynchpin to access ipso carbon-carbon, carbon-nitrogen, carbon oxygen, and carbon-halogen (Cl, Br, I) bonds. The utility of our methodology is illustrated through quick, modular syntheses of the pharmaceuticals Abilify and Flunixin.