Elucidating the neuronal architecture of olfactory glomeruli in the Drosophila 
antennal lobe

Grabe, Veit; Baschwitz, Amelie; Dweck, Hany; Lavista Llanos, Sofia; Hansson, Bill S.; Sachse, Silke

doi:10.1016/j.celrep.2016.08.063

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Elucidating the neuronal architecture of olfactory glomeruli in the Drosophila antennal lobe

MPG-Autoren

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Grabe, Veit
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Baschwitz, Amelie
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Dweck, Hany
Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Lavista Llanos, Sofia
Research Group Dr. M. Stensmyr, Molecular Biology of Olfaction, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Hansson, Bill S.
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Sachse, Silke
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
Research Group Dr. S. Sachse, Olfactory Coding, MPI for Chemical Ecology, Max Planck Society;

Externe Ressourcen

http://dx.doi.org/10.1016/j.celrep.2016.08.063
(Verlagsversion)

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Zitation

Grabe, V., Baschwitz, A., Dweck, H., Lavista Llanos, S., Hansson, B. S., & Sachse, S. (2016). Elucidating the neuronal architecture of olfactory glomeruli in the Drosophila antennal lobe. Cell Reports, 16, 3401-3413. doi:10.1016/j.celrep.2016.08.063.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002B-2009-D

Zusammenfassung

Olfactory glomeruli are morphologically conserved
spherical compartments of the olfactory system,
distinguishable solely by their chemosensory repertoire,
anatomical position, and volume. Little is
known, however, about their numerical neuronal
composition. We therefore characterized their
neuronal architecture and correlated these anatomical
features with their functional properties in
Drosophila melanogaster.We quantitatively mapped
all olfactory sensory neurons (OSNs) innervating each
glomerulus, including sexually dimorphic distributions.
Our data reveal the impact of OSN number on
glomerular dimensions and demonstrate yet unknown
sex-specific differences in several glomeruli.
Moreover, we quantified uniglomerular projection
neurons for each glomerulus, which unraveled a
glomerulus-specific numerical innervation. Correlation
between morphological features and functional
specificity showed that glomeruli innervated by
narrowly tuned OSNs seem to possess a larger number
of projection neurons and are involved in less
lateral processing than glomeruli targeted by broadly
tuned OSNs. Our study demonstrates that the
neuronal architecture of each glomerulus encoding crucial odors is unique.