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Cellular Homeostasis and Aging

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Hartl,  F. Ulrich
Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Hartl, F. U. (2016). Cellular Homeostasis and Aging. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85, 85, 1-4. doi:10.1146/annurev-biochem-011116-110806.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002B-1EAE-C
Abstract
Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events that interface with environmental factors to maintain cellular homeostasis. Modulation of these pathways to extend life span, including insulin-like signaling and the response to dietary restriction, identified the cellular machineries and networks of protein homeostasis (proteostasis) and stress resistance pathways as critical players in the aging process. A decline of proteostasis capacity during aging leads to dysfunction of specific cell types and tissues, rendering the organism susceptible to a range of chronic diseases. This volume of the Annual Review of Biochemistry contains a set of two reviews addressing our current understanding of the molecular mechanisms underlying aging in model organisms and humans.