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Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus

MPG-Autoren
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Steele,  Christopher
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Anwander,  Alfred
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Bazin,  Pierre-Louis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel,  Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Schäfer,  Andreas
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Turner,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Steele, C., Anwander, A., Bazin, P.-L., Trampel, R., Schäfer, A., Turner, R., et al. (2017). Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus. Cerebral Cortex, 27(9), 4537-4548. doi:10.1093/cercor/bhw258.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002B-4958-B
Zusammenfassung
The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behavior form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus of the cerebellum, contains topographically distinct connections to both motor and non-motor regions, yet there is no evidence for how the cerebellar cortex connects to the dentate nuclei in humans. Here we used in-vivo sub-millimeter diffusion imaging to characterize this fundamental component of the cortico-cerebellar loop, and identified a pattern of superior motor and infero-lateral non-motor connectivity strikingly similar to that proposed by animal work. Crucially, we also present first evidence that the dominance for motor connectivity observed in non-human primates may be significantly reduced in man – a finding that is in accordance with the proposed increase in cerebellar contributions to higher cognitive behavior over the course of primate evolution.