Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase.

Levchenko, M.; Wuttke, J. M.; Römpler, K.; Schmidt, B.; Neifer, K.; Juris, L.; Wissel, M.; Rehling, P.; Deckers, M.

doi:10.1016/j.bbamcr.2016.04.007

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Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase.

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http://www.sciencedirect.com/science/article/pii/S016748891630088X/pdfft?md5=e3e5b45422a869cf66a0361c3a260314&pid=1-s2.0-S016748891630088X-main.pdf
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引用

Levchenko, M., Wuttke, J. M., Römpler, K., Schmidt, B., Neifer, K., Juris, L., Wissel, M., Rehling, P., & Deckers, M. (2016). Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. Biochimica et Biophysica Acta - Molecular Cell Research, 1863(7), 1624-1632. doi:10.1016/j.bbamcr.2016.04.007.

引用: https://hdl.handle.net/11858/00-001M-0000-002A-FF95-3

要旨

The cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. The complex accepts electrons from cytochrome c and passes them onto molecular oxygen. This process contributes to energy capture in the form of a membrane potential across the inner membrane. The enzyme complex assembles in a stepwise process from the three mitochondria-encoded core subunits Coxl, Cox2 and Cox3, which associate with nuclear-encoded subunits and cofactors. In the yeast Saccharomyces cerevisiae, the cytochrome c oxidase associates with the bc(1)-complex into supercomplexes, allowing efficient energy transduction. Here we report on Cox26 as a protein found in respiratory chain supercomplexes containing cytochrome c oxidase. Our analyses reveal Cox26 as a novel stoichiometric structural subunit of the cytochrome c oxidase. A loss of Cox26 affects cytochrome c oxidase activity and respirasome organization.