Synthetic strategies for preparation of cyclen-based MRI contrast agents

Cakić, N; Gündüz, S; Rengarasu, R; Angelovski, G

doi:10.1016/j.tetlet.2014.12.087

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Synthetic strategies for preparation of cyclen-based MRI contrast agents

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Cakić, N
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Gündüz, S
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Rengarasu, R
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski, G
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/S0040403914021534
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Citation

Cakić, N., Gündüz, S., Rengarasu, R., & Angelovski, G. (2015). Synthetic strategies for preparation of cyclen-based MRI contrast agents. Tetrahedron Letters, 56(6), 759-765. doi:10.1016/j.tetlet.2014.12.087.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-4774-E

Abstract

Cyclen-based macrocyclic ligands have an essential role in the development of contrast agents for magnetic resonance imaging (MRI). A prevailing need for preparation of multifunctional probes triggered a number of attempts to synthesize and derivatise ligands which efficiently chelate lanthanide ions and have advantageous MRI properties. This digest article summarizes the most common synthetic approaches for the preparation of macrocyclic ligands based on cyclen depending on the desired application.