Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of 
Ischemic Stroke

Tang, Y-H; Ma, Y-Y; Zhang, Z.J; Wang, Y-T; Yang, G-Y

doi:10.1111/cns.12386

Item

ITEM ACTIONSEXPORT

Add to Basket

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_2272520_3

DetailsSummary

Released

Journal Article

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke

MPS-Authors

/persons/resource/persons192855

Tang, Y-H
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Tang, Y.-H., Ma, Y.-Y., Zhang, Z., Wang, Y.-T., & Yang, G.-Y. (2015). Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke. CNS Neuroscience Therapeutics, 21(4), 337–347. doi:10.1111/cns.12386.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-46A0-1

Abstract

Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-based therapy is still in its infancy. The next decade of stem cell research in stroke field needs to focus on combining different stem cells and different imaging modalities to fully explore the potential of this therapeutic avenue: from bench to bedside and vice versa.