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Journal Article

Towards the Production of Universal Blood by Structure-Guided Directed Evolution of Glycoside Hydrolases

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Sun,  Zhoutong
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Ilie,  Adriana
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Reetz, M. T., Sun, Z., & Ilie, A. (2015). Towards the Production of Universal Blood by Structure-Guided Directed Evolution of Glycoside Hydrolases. Angewandte Chemie International Edition, 54, 9158-9160. doi:10.1002/anie.201504318.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-2930-7
Abstract
Coming closer to a vision: Directed evolution has been applied to a glycoside hydrolase for increased activity in the selective cleavage of A- and B-antigens from linkages on red blood cell surface glycans. The results are a major step forward in the challenging endeavor of producing universal blood.