Sleep-active neuron specification and sleep induction require FLP-11 
neuropeptides to systemically induce sleep.

Turek, M.; Besseling, J.; Spies, J. P.; König, S.; Bringmann, H.

doi:10.7554/eLife.12499

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.

MPS-Authors

/persons/resource/persons136383

Turek, M.
Research Group of Sleep and Waking, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons173776

Besseling, J.
Research Group of Sleep and Waking, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons186221

Spies, J. P.
Research Group of Sleep and Waking, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons192070

König, S.
Research Group of Sleep and Waking, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons14894

Bringmann, H.
Research Group of Sleep and Waking, MPI for Biophysical Chemistry, Max Planck Society;

External Resource

https://elife-publishing-cdn.s3.amazonaws.com/12499/elife-12499-v2-download.pdf
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

2262117.pdf
(Publisher version), 4MB

Supplementary Material (public)

There is no public supplementary material available

Citation

Turek, M., Besseling, J., Spies, J. P., König, S., & Bringmann, H. (2016). Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. eLife, 5: e12499. doi:10.7554/eLife.12499.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-1C36-4

Abstract

Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that express GABA. However, little is known about how sleep neuron function is determined and how sleep neurons change physiology and behavior systemically. Here, we investigated sleep in Caenorhabditis elegans, which is induced by the single sleep-active neuron RIS. We found that the transcription factor LIM-6, which specifies GABAergic function, in parallel determines sleep neuron function through the expression of APTF-1, which specifies the expression of FLP-11 neuropeptides. Surprisingly FLP-11, and not GABA, is the major component that determines the sleep-promoting function of RIS. FLP-11 is constantly expressed in RIS. At sleep onset RIS depolarizes and releases FLP-11 to induce a systemic sleep state.