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Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4

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Almeida,  Andreia
Daniel Kolarich, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Kolarich,  Daniel
Daniel Kolarich, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Zitation

Mereiter, S., Magalhães, A., Adamczyk, B., Jin, C., Almeida, A., Drici, L., et al. (2016). Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4. Data in Brief, 7, 814-833. doi:10.1016/j.dib.2016.03.022.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-22D1-8
Zusammenfassung
Gastric carcinoma \MKN45\} cells stably transfected with the full-length \{ST3GAL4\} gene were characterised by glycomic and sialoproteomic analysis. Complementary strategies were applied to assess the glycomic alterations induced by \{ST3GAL4\} overexpression. The N-and O-glycome data were generated in two parallel structural analyzes, based on PGC-ESI-MS/MS. Data on glycan structure identification and relative abundance in \{ST3GAL4\} overexpressing cells and respective mock control are presented. The sialoproteomic analysis based on titanium-dioxide enrichment of sialopeptides with subsequent LC-MS/MS identification was performed. This analysis identified 47 proteins with significantly increased sialylation. The data in this article is associated with the research article published in Biochim Biophys Acta “Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of \{RON\ receptor tyrosine kinase activation in cancer” [1].