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Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses

MPG-Autoren
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Bisenius,  Sandrine
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Neumann,  Jane
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;

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Schroeter,  Matthias L.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;
Consortium for Frontotemporal Lobar Degeneration, Leipzig, Germany;

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Zitation

Bisenius, S., Neumann, J., & Schroeter, M. L. (2016). Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses. European Journal of Neurology, 23(4), 704-712. doi:10.1111/ene.12902.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-1098-C
Zusammenfassung
Recently, diagnostic clinical and imaging criteria for primary progressive aphasia (PPA) have been revised by an international consortium (Gorno-Tempini et al. Neurology 2011;76:1006-14). The aim of this study was to validate the specificity of the new imaging criteria and investigate whether different imaging modalities [magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET)] require different diagnostic subtype-specific imaging criteria. Anatomical likelihood estimation meta-analyses were conducted for PPA subtypes across a large cohort of 396 patients: firstly, across MRI studies for each of the three PPA subtypes followed by conjunction and subtraction analyses to investigate the specificity, and, secondly, by comparing results across MRI vs. FDG-PET studies in semantic dementia and progressive nonfluent aphasia. Semantic dementia showed atrophy in temporal, fusiform, parahippocampal gyri, hippocampus, and amygdala, progressive nonfluent aphasia in left putamen, insula, middle/superior temporal, precentral, and frontal gyri, logopenic progressive aphasia in middle/superior temporal, supramarginal, and dorsal posterior cingulate gyri. Results of the disease-specific meta-analyses across MRI studies were disjunct. Similarly, atrophic and hypometabolic brain networks were regionally dissociated in both semantic dementia and progressive nonfluent aphasia. In conclusion, meta-analyses support the specificity of new diagnostic imaging criteria for PPA and suggest that they should be specified for each imaging modality separately.