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Journal Article

Aneuploidy and proteotoxic stress in cancer

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Donnelly,  Neysan
Storchova, Zuzana / Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Max Planck Society;

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Storchova,  Zuzana
Storchova, Zuzana / Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Donnelly, N., & Storchova, Z. (2015). Aneuploidy and proteotoxic stress in cancer. Molecular & Cellular Oncology, 2(2): e976491. doi:10.4161/23723556.2014.976491.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-B416-8
Abstract
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our fi ndings implicate HSF1 as a key factor in mitigating the effects of aneuploidy