The inner workings of AMPA receptors

Madden, Dean R.

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

The inner workings of AMPA receptors

MPS-Authors

/persons/resource/persons94176

Madden, Dean R.
Max Planck Research Group Ion Channel Structure (Dean R. Madden), Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.biomedcentral.com/pubmed/12630294
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Madden, D. R. (2002). The inner workings of AMPA receptors. Current Opinion in Drug Discovery Development, 5(5), 741-748. Retrieved from http://www.biomedcentral.com/pubmed/12630294.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-71BB-8

Abstract

As with all ligand-gated ion channels, ionotropic glutamate receptors (iGluRs) convert the free energy of agonist-binding into a sequence of conformational changes that allow regulated ion flux across an otherwise insulating membrane bilayer. In the case of iGluRs, the resulting membrane depolarization is a key mediator of intercellular signals in the synapses of the CNS. Recent biomedical and structural research has greatly expanded our understanding of the chemistry of iGluR agonist binding, and of the subsequent molecular changes that drive channel gating and desensitization.