English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes

MPS-Authors
/persons/resource/persons93510

Hutter,  Harald
Max Planck Research Group Developmental Genetics of the nervous system (Harald Hutter), Max Planck Institute for Medical Research, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Hutter, H., Vogel, B. E., Plenefisch, J. D., Norris, C. R., Proenca, R. B., Spieth, J., et al. (2000). Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes. Science, 287(5455), 989-994. doi:10.1126/science.287.5455.989.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-3537-B
Abstract
New proteins and modules have been invented throughout evolution. Gene birth dates in Caenorhabditis elegans range from the origins of cellular life through adaptation to a soil habitat. Possibly half are metazoan genes, having arisen sometime between the yeast-metazoan and nematode-chordate separations. These include basement membrane and cell adhesion molecules implicated in tissue organization. By contrast, epithelial surfaces facing the environment have specialized components invented within the nematode lineage. Moreover, interstitial matrices were likely elaborated within the vertebrate lineage. A strategy for concerted evolution of new gene families, as well as conservation of adaptive genes, may underlie the differences between heterochromatin and euchromatin.