Role and control of X chromosome dosage in mammalian development

Schulz, Edda G.; Heard, Edith

doi:10.1016/j.gde.2013.01.008

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Role and control of X chromosome dosage in mammalian development

MPG-Autoren

/persons/resource/persons145411

Schulz, Edda G.
Regulatory Networks in Stem Cells (Edda G. Schulz), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

Externe Ressourcen

Es sind keine externen Ressourcen hinterlegt

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Schulz.pdf
(Verlagsversion), 2MB

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Schulz, E. G., & Heard, E. (2013). Role and control of X chromosome dosage in mammalian development. Current Opinion in Genetics & Development, 23(2), 109-115. doi:10.1016/j.gde.2013.01.008.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0027-A220-1

Zusammenfassung

Many species have evolved sex chromosomes with highly divergent gene content, such as the X and Y chromosomes in mammals. As most non sex-specific genes probably need to be expressed at similar levels in males and females, dosage compensation mechanisms are in place to equalize the gene dosage between the sexes, and possibly also between sex chromosomes and autosomes. In mammals, one out of two X chromosomes is inactivated early during development in a process called X-chromosome inactivation that has been investigated intensively in the 50 years since it was discovered. Less is known about the potential functional roles of X-linked gene dosage, for example in controlling development in a sex-specific manner. In this review, we discuss the evolution of dosage compensation and how it is controlled during embryogenesis of mammals. In addition we will summarize evidence on the potential role of X chromosome number during early development.