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MicroRNA-9 controls dendritic development by targeting REST

MPG-Autoren
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Giusti,  Sebastian A.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Vogl,  Annette M.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Brockmann,  Marisa M.
external;
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

Vercelli,  Claudia A.
Department of Molecular Neurobiology, Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society;

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Deussing,  Jan M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Refojo,  Damian
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Zitation

Giusti, S. A., Vogl, A. M., Brockmann, M. M., Vercelli, C. A., Rein, M. L., Truembach, D., et al. (2014). MicroRNA-9 controls dendritic development by targeting REST. ELIFE, 3: UNSP e02755. doi:10.7554/eLife.02755.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0026-CE4D-5
Zusammenfassung
MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.