Bispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin. Synthesis, 
Structures, and Cytotoxicity

Cui, Huiling; Goddard, Richard; Pörschke, Klaus-Richard; Hamacher, Alexandra; Kassack, Matthias

doi:10.1021/ic402737f

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Bispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin. Synthesis, Structures, and Cytotoxicity

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Cui, Huiling
Research Group Pörschke, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Goddard, Richard
Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Pörschke, Klaus-Richard
Research Group Pörschke, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Cui, H., Goddard, R., Pörschke, K.-R., Hamacher, A., & Kassack, M. (2014). Bispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin. Synthesis, Structures, and Cytotoxicity. Inorganic Chemistry, 53(7), 3371-3384. doi:10.1021/ic402737f.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-9B23-F

Abstract

Bispidine analogues 1−3 of cisplatin, carboplatin, and oxaliplatin have been prepared, including some DMF and water solute complexes. The crystal structures reveal various patterns of N−H···Cl and N−H···O hydrogen bonds. For the hydrates of 1 and 2, different modes of water solvation were found. The compounds have been tested for their cytotoxicity against standard human cancer cell lines, revealing significant cytotoxic activity along with a low platinum resistance factor R.