Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone 
structure.

Schmidtgall, B.; Spork, A. P.; Wachowius, F.; Höbartner, C.; Ducho, C.

doi:10.1039/C4CC06371F

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Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.

MPG-Autoren

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Wachowius, F.
Research Group of Nucleic Acid Chemistry, MPI for biophysical chemistry, Max Planck Society;

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Höbartner, C.
Research Group of Nucleic Acid Chemistry, MPI for biophysical chemistry, Max Planck Society;

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http://pubs.rsc.org/en/content/articlepdf/2014/cc/c4cc06371f
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Zitation

Schmidtgall, B., Spork, A. P., Wachowius, F., Höbartner, C., & Ducho, C. (2014). Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure. Chemical Communications, 50(89), 13742-13745. doi:10.1039/C4CC06371F.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0024-445C-A

Zusammenfassung

The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.