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Progress in microchip enantioseparations

MPS-Authors
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Nagl,  S.
Institute of Analytical Chemistry, University of Leipzig, Leipzig, Germany;
Service Department Schulze (GC, HPLC), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Schulze,  P.
Institute of Analytical Chemistry, University of Leipzig, Leipzig, Germany;
Service Department Schulze (GC, HPLC), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

Ludwig,  M.
Institute of Analytical Chemistry, University of Leipzig, Leipzig, Germany;
Research Group Belder, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Belder,  D.
Institute of Analytical Chemistry, University of Leipzig, Leipzig, Germany;
Research Group Belder, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Nagl, S., Schulze, P., Ludwig, M., & Belder, D. (2009). Progress in microchip enantioseparations. Electrophoresis, 30(16), 2765-2772. doi:10.1002/elps.200900153.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-424B-B
Abstract
Advances in microfluidic chips for chiral separations from 2003 to early 2009 are discussed. Microchip-based separation techniques promise higher speed, throughput, portability, less sample and reagent consumption, better environmental compatibility, reduced cost and the prospect of system integration. Microchip electrophoresis is the most promising technique for miniaturized enantioseparations and has been performed with a variety of designs and analytes, however, other formats such as microchip electrochromatography are also gaining in popularity. Microchip fabrication, chemistry and detection issues are critically discussed and highlighted. Integration of enantioseparation techniques into multifunctional microchips are currently a rapidly advancing area of research and methods are discussed that may eventually enable enantioseparations to be the part of a holistic chemical microchip.