Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene 
product p21 complexed with GTP analogues

Scherer, Anna; John, Jacob; Linke, R.; Goody, Roger S.; Wittinghofer, Alfred; Pai, Emil F.; Holmes, Kenneth C.

doi:10.1016/0022-2836(89)90540-8

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Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues

MPG-Autoren

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Scherer, Anna
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Goody, Roger S.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Wittinghofer, Alfred
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Holmes, Kenneth C.
Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society;
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Muscle Research, Max Planck Institute for Medical Research, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/0022283689905408/pdf?md5=4a6733900a32f0cfe2945904b093b951&pid=1-s2.0-0022283689905408-main.pdf
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https://doi.org/10.1016/0022-2836(89)90540-8
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Zitation

Scherer, A., John, J., Linke, R., Goody, R. S., Wittinghofer, A., Pai, E. F., et al. (1989). Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues. Journal of Molecular Biology (London), 206(1), 257-259. doi:10.1016/0022-2836(89)90540-8.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0019-ADD4-A

Zusammenfassung

The catalytic domain (amino acid residues 1 to 166) of the human ras-oncogene product p21 complexed with the GTP analogues beta,gamma-imido-GTP (GMPPNP), beta,gamma-methylene-GTP (GMPPCP), and guanosine-5'-(gamma-thiotriphosphate) (GTP gamma S) have been been crystallized. Crystals of the GMPPNP and GMPPCP complexes are well suited for high resolution X-ray crystallography. They belong to space group P3(1)21 (or its enantiomorph P3(2)21) with unit cell axes a=b=40.3 A and c = 162.2 A.