Organisation of the murine 5-HT3 receptor gene and assignment to human 
chromosome 11

Uetz, Peter; Abdelatty, Fawzy; Villarroel, Alfredo; Rappold, Gudrun A.; Weiss, Birgit; Koenen, Michael

doi:10.1016/0014-5793(94)80435-4

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Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11

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Uetz, Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Villarroel, Alfredo
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Koenen, Michael
Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society;
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society;
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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https://dx.doi.org/10.1016/0014-5793(94)80435-4
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Citation

Uetz, P., Abdelatty, F., Villarroel, A., Rappold, G. A., Weiss, B., & Koenen, M. (1994). Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11. FEBS Letters, 339(3), 302-306. doi:10.1016/0014-5793(94)80435-4.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A939-4

Abstract

We have isolated the murine gene encoding the 5−HT₃ receptor (5−HT₃R), a member of the ligand−gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5−HT₃R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5−HT₃R variants. The 5−HT₃R gene, whose structure is closely related to neuronal and muscle AchRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11