The swinging lever-arm hypothesis of muscle contraction

Holmes, Kenneth C.

doi:10.1016/S0960-9822(06)00051-0

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The swinging lever-arm hypothesis of muscle contraction

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Holmes, Kenneth C.
Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society;
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Muscle Research, Max Planck Institute for Medical Research, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/S0960982206000510/pdfft?md5=9a21ed03df3dcedf7bc64697e2c745d3&pid=1-s2.0-S0960982206000510-main.pdf
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Citation

Holmes, K. C. (1997). The swinging lever-arm hypothesis of muscle contraction. Current Biology, 7(2), R112-R118. doi:10.1016/S0960-9822(06)00051-0.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A5FA-1

Abstract

The molecular mechanism of muscle contraction is a problem that has exercised biophysicists and biochemists for many years. The common view of the mechanism is embodied in the ‘cross-bridge hypothesis’, in which the relative sliding of thick (myosin) and thin (actin) filaments in cross-striated muscle is brought about by the ‘cross-bridges’, parts of the myosin molecules which protrude from the thick filaments and interact cyclically with the actin filaments, transporting them by a rowing action that is powered by the hydrolysis of ATP. This hypothesis is, however, rather vague on the molecular details of cross-bridge movement and, in the light of the recently determined crystal structures of myosin and actin, it has evolved into the more precise ‘swinging lever-arm hypothesis’.