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Journal Article

Pax-2 in the chiasm

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Schwarz,  Martin K.
Martin Schwarz Group, Max Planck Institute for Medical Research, Max Planck Society;
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Alvarez−Bolado, G., Schwarz, M. K., & Gruss, P. (1997). Pax-2 in the chiasm. Cell and Tissue Research, 290(2), 197-200. doi:10.1007/s004410050923.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A580-4
Abstract
Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.