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Journal Article

Role of an A−type K+ conductance in the back−propagation of action potentials in the dendrites of hippocampal pyramidal neurons

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Hoffman, Dax A.
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;
Synaptic Plasticity and Behaviour, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Migliore, M., Hoffman, D. A., Magee, J. C., & Johnston, D. (1999). Role of an A−type K+ conductance in the back−propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J. Comput. Neurosci., 7: 231549, pp. 5-15. doi:10.1023/A:1008906225285.

Abstract

Action potentials elicited in the axon actively back−propagate into the dendritic tree. During this process their amplitudes can be modulated by internal and external factors. We used a compartmental model of a hippocampal CA1 pyramidal neuron to illustrate how this modulation could depend on (1) the properties of an A−type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation. The simulations suggest that the time relationship between pre− and postsynaptic activity could help regulate the amplitude of back−propagating action potentials, especially in the distal portion of the dendritic tree