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Journal Article

Products of Cytochrome P450_BioI (CYP107H1)−Catalyzed Oxidation of Fatty Acids

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Cryle, Max
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;
Cytochrome P450, Max Planck Institute for Medical Research, Max Planck Society;
Heme and Flavin Enzymes, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Cryle, M., Matovic, N. J., & De Voss, J. J. (2003). Products of Cytochrome P450_BioI (CYP107H1)−Catalyzed Oxidation of Fatty Acids. Organic Letters, 5(18), 3341-3344. doi:10.1021/ol035254e.

Abstract

Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450_BioI (CYP107H1) produces mainly the 11−, 12−, and 13−hydroxy C₁₄ fatty acids and the 11− to 15−hydroxy C₁₆ fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450_BioI was also determined, and the enzyme was shown to be moderately selective for production of the (R)−alcohols