Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with 
human STAT3β protein.

Chua, J. J. E.; Bhuvanakantham, R.; Chow, V. T. K.; Ng, M. L.

doi:10.1016/j.virusres.2005.03.025

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Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein.

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Chua, J. J. E.
Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/S0168170205000924/pdfft?md5=7b6ecb7d106db608ea9ef402d78c8f3b&pid=1-s2.0-S0168170205000924-main.pdf
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Citation

Chua, J. J. E., Bhuvanakantham, R., Chow, V. T. K., & Ng, M. L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research, 112(1-2), 85-94. doi:10.1016/j.virusres.2005.03.025.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0018-0A99-D

Abstract

A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome.