A gradual increase of iron toward the medial-inferior tip of the subthalamic 
nucleus

de Hollander, Gilles; Keuken, Max; Bazin, Pierre-Louis; Weiss, Marcel; Neumann, Jane; Reimann, Katja; Wähnert, Miriam; Turner, Robert; Forstmann, Birte U.; Schäfer, Andreas

doi:10.1002/hbm.22485

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A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus

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Keuken, Max
University of Amsterdam, Amsterdam Brain Center, Amsterdam, the Netherlands;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Bazin, Pierre-Louis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiss, Marcel
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Neumann, Jane
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany;

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Reimann, Katja
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Wähnert, Miriam
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Turner, Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Schäfer, Andreas
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

de Hollander, G., Keuken, M., Bazin, P.-L., Weiss, M., Neumann, J., Reimann, K., et al. (2014). A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus. Human Brain Mapping, 35(9), 4440-4449. doi:10.1002/hbm.22485.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-18D3-0

Abstract

The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson’s disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows for detailed assessment of iron content in both in vivo and postmortem tissue. Twelve human participants and 7 postmortem brain samples containing the STN were scanned using ultra-high field 7 Tesla (T) MRI. Iron concentrations were found to be higher in the medial-inferior tip of the STN. Using quantitative methods we show that the increase of iron concentration towards the medial-inferior tip is of a gradual rather than a discrete nature.