Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Ultra-high 7T MRI of structural age-related changes of the subthalamic nucleus

MPG-Autoren
/persons/resource/persons23475

Bazin,  Pierre-Louis
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19963

Schäfer,  Andreas
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19887

Neumann,  Jane
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;

/persons/resource/persons20055

Turner,  Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Keuken, M., Bazin, P.-L., Schäfer, A., Neumann, J., Turner, R., & Forstmann, B. U. (2013). Ultra-high 7T MRI of structural age-related changes of the subthalamic nucleus. The Journal of Neuroscience, 33(11), 4896-4900. doi:10.1523/JNEUROSCI.3241-12.2013.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-000E-7DEF-3
Zusammenfassung
The subthalamic nucleus (STh) is a small subcortical structure which is involved in regulating motor as well as cognitive functions. Due to its small size and close proximity to other small subcortical structures, it has been a challenge to localize and visualize it using magnetic resonance imaging (MRI). Currently there are several standard atlases available that are used to localize the STh in functional MRI studies and clinical procedures such as deep brain stimulation (DBS). DBS is an increasingly common neurosurgical procedure that has been successfully used to alleviate motor symptoms present in Parkinson's disease. However, current atlases are based on low sample sizes and restricted age ranges (Schaltenbrand and Wahren, 1977), and hence the use of these atlases effectively ignores the substantial structural brain changes that are associated with aging. In the present study, ultra-high field 7 tesla (T) magnetic resonance imaging (MRI) in humans was used to visualize and segment the STh in young, middle-aged, and elderly participants. The resulting probabilistic atlas maps for all age groups show that the STh shifts in the lateral direction with increasing age. In sum, the results of the present study suggest that age has to be taken into account in atlases for the optimal localization of the STh in healthy and diseased brains.