Timing and mechanism of ancient vertebrate genome duplications – the adventure 
of a hypothesis

Panopoulou, Georgia; Poustka, Albert J.

doi:10.1016/j.tig.2005.08.004

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Timing and mechanism of ancient vertebrate genome duplications – the adventure of a hypothesis

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Panopoulou, Georgia
Evolution and Development (Albert Poustka), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Poustka, Albert J.
Evolution and Development (Albert Poustka), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Panopoulou, G., & Poustka, A. J. (2005). Timing and mechanism of ancient vertebrate genome duplications – the adventure of a hypothesis. Trend in Genetics (Amsterdam), 21, 559-567. doi:10.1016/j.tig.2005.08.004.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-85C4-F

Abstract

Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of vertebrates (known as the 2R hypothesis). However, there has been considerable debate as to whether these were two successive duplications, or whether a single duplication occurred, followed by large-scale segmental duplications. In this article, we review and compare the evidence for the 2R duplications from vertebrate genomes with similar data from other more recent polyploids.