Generating a Spread Out Bragg Peak to Investigate the Relative Biological 
Effectiveness (RBE) of Antiprotons

Straße, Tina

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Generating a Spread Out Bragg Peak to Investigate the Relative Biological Effectiveness (RBE) of Antiprotons

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Straße, Tina
Carsten Welsch - Helmholtz University Group, Junior Research Groups, MPI for Nuclear Physics, Max Planck Society;

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Citation

Straße, T. (2011). Generating a Spread Out Bragg Peak to Investigate the Relative Biological Effectiveness (RBE) of Antiprotons. Diploma Thesis, Ruprecht-Karls-Universität, Heidelberg, Germany.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-2D40-8

Abstract

This thesis deals with the investigation of the biological effectiveness of antiprotons on V79-WNRE cells (Chinese hamster lung fibroblasts). It describes the development and operation of an automated, remotely controllable energy changing device to produce a clinically relevant dose profile. Moreover, for the first time, the use of a " ripple" filter for further optimization of the profile in an antiproton beam is discussed and analyzed. A broadening of the measured dose profile of 12 % compared to the ripplefilter- free beam, is in good agreement with the theoretical predicted 15 %. Due to the constraints with resprect to the experimental set-up imposed by the Antiproton Decelerator (AD at CERN) and the resulting long irradiation times, the biological data set is rather sparse, which complicates the statistical analysis. Because of this, a detailed discussion on the calculation of the standard deviation of cell survival rates is performed. Fnrthermore, a new concept is introduced, which unifies the analysis and includes statistical fluctuat ions.