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Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons4251

Wicher,  D.
Department of Neuroethology, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons4138

Schäfer,  R.
Department of Neuroethology, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons3793

Bauernfeind,  R.
Department of Neuroethology, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons4194

Stensmyr,  M. C.
Department of Neuroethology, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons3909

Hansson,  B. S.
Department of Neuroethology, MPI for Chemical Ecology, Max Planck Society;

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Citation

Wicher, D., Schäfer, R., Bauernfeind, R., Stensmyr, M. C., Heller, R., Heinemann, S. H., et al. (2008). Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature, 452(7190), 1007-1011. doi:10.1038/nature06861.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A949-E
Abstract
From worm to man, many odorant signals are perceived by the binding of volatile ligands to odorant receptors(1) that belong to the G- protein- coupled receptor ( GPCR) family(2). They couple to heterotrimeric G- proteins, most of which induce cAMP produ