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Automated glycan assembly using the Glyconeer 2.1 synthesizer

MPG-Autoren
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Hahm,  Heung Sik
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;
Institute of Chemistry and Biochemistry, Free University Berlin;

/persons/resource/persons121819

Schlegel,  Mark K.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;
GlycoUniverse GmbH & Co. KGaA;

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Hurevich,  Mattan
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Eller,  Steffen
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons128892

Schuhmacher,  Frank
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;
Institute of Chemistry and Biochemistry, Free University Berlin;

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Hofmann,  Johanna
Molecular Physics, Fritz Haber Institute, Max Planck Society;
Institute of Chemistry and Biochemistry, Free University Berlin;

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Pagel,  Kevin
Molecular Physics, Fritz Haber Institute, Max Planck Society;
Institute of Chemistry and Biochemistry, Free University Berlin;

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Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;
Institute of Chemistry and Biochemistry, Free University Berlin;

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Zitation

Hahm, H. S., Schlegel, M. K., Hurevich, M., Eller, S., Schuhmacher, F., Hofmann, J., et al. (2017). Automated glycan assembly using the Glyconeer 2.1 synthesizer. Proceedings of the National Academy of Sciences of the United States of America, 114(17), E3385-E3389. doi:10.1073/pnas.1700141114.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002D-3E90-E
Zusammenfassung
Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure–activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosaccharides using the commercially available Glyconeer 2.1 automated glycan synthesizer, monosaccharide building blocks, and a linker-functionalized polystyrene solid support. Purification and quality-control protocols for the oligosaccharide products have been standardized. Synthetic glycans prepared in this way are useful reagents as the basis for glycan arrays, diagnostics, and carbohydrate-based vaccines.