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Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons199050

Shemesh,  Yair
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202031

Forkosh,  Oren
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202033

Anpilov,  Sergey
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons201678

Manashirov,  Sharon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202037

Shlapobersky,  Tamar
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202039

Ezra,  Gili
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202041

Adler,  Elaine
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202043

Ben-Efraim,  Yair J
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons202045

Shosh,  Gil
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80306

Dine,  Julien
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80315

Eder,  Matthias
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80301

Deussing,  Jan M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons129892

Chen,  Alon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

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Citation

Shemesh, Y., Forkosh, O., Mahn, M., Anpilov, S., Sztainberg, Y., Manashirov, S., et al. (2016). Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. NATURE NEUROSCIENCE, 19(11), 1489-1496. doi:10.1038/nn.4346.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-4291-1
Abstract
Social encounters are associated with varying degrees of emotional arousal and stress. The mechanisms underlying adequate socioemotional balance are unknown. The medial amygdala (MeA) is a brain region associated with social behavior in mice. Corticotropin-releasing factor receptor type-2 (CRF-R2) and its specific ligand urocortin-3 (Ucn3), known components of the behavioral stress response system, are highly expressed in the MeA. Here we show that mice deficient in CRF-R2 or Ucn3 exhibit abnormally low preference for novel conspecifics. MeA-specific knockdown of Crfr2 (Crhr2) in adulthood recapitulated this phenotype. In contrast, pharmacological activation of MeA CRF-R2 or optogenetic activation of MeA Ucn3 neurons increased preference for novel mice. Furthermore, chemogenetic inhibition of MeA Ucn3 neurons elicited pro-social behavior in freely behaving groups of mice without affecting their hierarchal structure. These findings collectively suggest that the MeA Ucn3 CRF-R2 system modulates the ability of mice to cope with social challenges.