Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Shemesh, Yair; Forkosh, Oren; Mahn, Mathias; Anpilov, Sergey; Sztainberg, Yehezkel; Manashirov, Sharon; Shlapobersky, Tamar; Elliott, Evan; Tabouy, Laure; Ezra, Gili; Adler, Elaine; Ben-Efraim, Yair J; Shosh, Gil; Kuperman, Yael; Haramati, Sharon; Dine, Julien; Eder, Matthias; Deussing, Jan M.; Schneidman, Elad; Yizhar, Ofer; Chen, Alon

doi:10.1038/nn.4346

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Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

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Shemesh, Yair
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202031

Forkosh, Oren
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202033

Anpilov, Sergey
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons201678

Manashirov, Sharon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202037

Shlapobersky, Tamar
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202039

Ezra, Gili
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202041

Adler, Elaine
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202043

Ben-Efraim, Yair J
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons202045

Shosh, Gil
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons80306

Dine, Julien
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80315

Eder, Matthias
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80301

Deussing, Jan M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons129892

Chen, Alon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

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Citation

Shemesh, Y., Forkosh, O., Mahn, M., Anpilov, S., Sztainberg, Y., Manashirov, S., et al. (2016). Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. NATURE NEUROSCIENCE, 19(11), 1489-1496. doi:10.1038/nn.4346.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-4291-1

Abstract

Social encounters are associated with varying degrees of emotional arousal and stress. The mechanisms underlying adequate socioemotional balance are unknown. The medial amygdala (MeA) is a brain region associated with social behavior in mice. Corticotropin-releasing factor receptor type-2 (CRF-R2) and its specific ligand urocortin-3 (Ucn3), known components of the behavioral stress response system, are highly expressed in the MeA. Here we show that mice deficient in CRF-R2 or Ucn3 exhibit abnormally low preference for novel conspecifics. MeA-specific knockdown of Crfr2 (Crhr2) in adulthood recapitulated this phenotype. In contrast, pharmacological activation of MeA CRF-R2 or optogenetic activation of MeA Ucn3 neurons increased preference for novel mice. Furthermore, chemogenetic inhibition of MeA Ucn3 neurons elicited pro-social behavior in freely behaving groups of mice without affecting their hierarchal structure. These findings collectively suggest that the MeA Ucn3 CRF-R2 system modulates the ability of mice to cope with social challenges.