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Region-specific roles of the corticotropin-releasing factor-urocortin system in stress

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons202314

Henckens,  Marloes J. A. G.
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80301

Deussing,  Jan M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons129892

Chen,  Alon
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Henckens, M. J. A. G., Deussing, J. M., & Chen, A. (2016). Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. NATURE REVIEWS NEUROSCIENCE, 17(10), 636-651. doi:10.1038/nrn.2016.94.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-4C28-C
Abstract
Dysregulation of the corticotropin-releasing factor ( CRF)-urocortin ( UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF-CRF receptor type 1 ( CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery and the restoration of homeostasis. Recent findings, however, provide clear evidence that this view is overly simplistic. Instead, a more complex picture has emerged that suggests that there are brain region-and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.