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Journal Article

Elucidating the neuronal architecture of olfactory glomeruli in the Drosophila antennal lobe

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons76357

Grabe,  Veit
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons49267

Baschwitz,  Amelie
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons71706

Dweck,  Hany
Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons37475

Lavista Llanos,  Sofia
Research Group Dr. M. Stensmyr, Molecular Biology of Olfaction, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons3909

Hansson,  Bill S.
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons4130

Sachse,  Silke
BMBF Research Group Dr. S. Sachse, Olfactory Coding, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Citation

Grabe, V., Baschwitz, A., Dweck, H., Lavista Llanos, S., Hansson, B. S., & Sachse, S. (2016). Elucidating the neuronal architecture of olfactory glomeruli in the Drosophila antennal lobe. Cell Reports, 16, 3401-3413. doi:10.1016/j.celrep.2016.08.063.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002B-2009-D
Abstract
Olfactory glomeruli are morphologically conserved spherical compartments of the olfactory system, distinguishable solely by their chemosensory repertoire, anatomical position, and volume. Little is known, however, about their numerical neuronal composition. We therefore characterized their neuronal architecture and correlated these anatomical features with their functional properties in Drosophila melanogaster.We quantitatively mapped all olfactory sensory neurons (OSNs) innervating each glomerulus, including sexually dimorphic distributions. Our data reveal the impact of OSN number on glomerular dimensions and demonstrate yet unknown sex-specific differences in several glomeruli. Moreover, we quantified uniglomerular projection neurons for each glomerulus, which unraveled a glomerulus-specific numerical innervation. Correlation between morphological features and functional specificity showed that glomeruli innervated by narrowly tuned OSNs seem to possess a larger number of projection neurons and are involved in less lateral processing than glomeruli targeted by broadly tuned OSNs. Our study demonstrates that the neuronal architecture of each glomerulus encoding crucial odors is unique.