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Brain regulation of food craving: Relationships with weight status and eating behavior

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons98496

Dietrich,  Anja
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19731

Hollmann,  Maurice
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons22901

Mathar,  David
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons20065

Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
University Hospital Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19734

Horstmann,  Annette
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
University Hospital Leipzig, Germany;

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Zitation

Dietrich, A., Hollmann, M., Mathar, D., Villringer, A., & Horstmann, A. (2016). Brain regulation of food craving: Relationships with weight status and eating behavior. International Journal of Obesity, 982-989. doi:10.1038/ijo.2016.28.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0029-5AD0-7
Zusammenfassung
Objectives: Food craving is a driving force for overeating and obesity. However, the relationship between brain mechanisms involved in its regulation and weight status is still an open issue. Gaps in the studied body mass index (BMI) distributions and focusing on linear analyses might have contributed to this lack of knowledge. Here, we investigated brain mechanisms of craving regulation using functional magnetic resonance imaging in a balanced sample including normal-weight, overweight and obese participants. We investigated associations between characteristics of obesity, eating behavior and regulatory brain function focusing on nonlinear relationships. Subjects/Methods: Forty-three hungry female volunteers (BMI: 19.4–38.8 kg m−2, mean: 27.5±5.3 s.d.) were presented with visual food stimuli individually pre-rated according to tastiness and healthiness. The participants were instructed to either admit to the upcoming craving or regulate it. We analyzed the relationships between regulatory brain activity as well as functional connectivity and BMI or eating behavior (Three-Factor Eating Questionnaire, scales: Cognitive Restraint, Disinhibition). Results: During regulation, BMI correlated with brain activity in the left putamen, amygdala and insula in an inverted U-shaped manner. Functional connectivity between the putamen and the dorsolateral prefrontal cortex (dlPFC) correlated positively with BMI, whereas that of amygdala with pallidum and lingual gyrus was nonlinearly (U-shaped) associated with BMI. Disinhibition correlated negatively with the strength of functional connectivity between amygdala and dorsomedial prefrontal (dmPFC) cortex as well as caudate. Conclusions: This study is the first to reveal quadratic relationships of food-related brain processes and BMI. Reported nonlinear associations indicate inverse relationships between regulation-related motivational processing in the range of normal weight/overweight compared with the obese range. Connectivity analyses suggest that the need for top-down (dlPFC) adjustment of striatal value representations increases with BMI, whereas the interplay of self-monitoring (dmPFC) or eating-related strategic action planning (caudate) and salience processing (amygdala) might be hampered with high Disinhibition.