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A novel mode of tangential migration of cortical projection neurons

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons182103

Britanova,  Olga V.
Molecular biology of neuronal signals, Max Planck Institute of Experimental Medicine, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons182064

Alifragis,  Pavlos
Molecular biology of neuronal signals, Max Planck Institute of Experimental Medicine, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons182226

Junek,  Stephan
Cortical development, Max Planck Institute of Experimental Medicine, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons15911

Tarabykin,  Victor
Molecular biology of neuronal signals, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Citation

Britanova, O. V., Alifragis, P., Junek, S., Jones, K., Gruss, P., & Tarabykin, V. (2006). A novel mode of tangential migration of cortical projection neurons. Developmental Biology, 298(1), 299-311.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-2617-8
Abstract
Projection neurons of the developing cerebral cortex are generated in the cerebral ventricular zone and subsequently move to the developing cortical plate via radial migration. Conversely, most inhibitory interneurons originate in the ganglionic eminences and enter the developing cortical plate by tangential migration. Using immunohistochemical analysis together with tracer labeling experiments in organotypic brain slices, we show that a portion of cortical projection neurons migrates tangentially over long distances. Lineage analysis revealed that these neurons are derived from Emx1+ cortical progenitors and express the transcription factor Satb2 but do not express GABA or Olig1. In vitro and in vivo analysis of reeler mutant brains demonstrated that although reeler mutation does not influence tangential migration of interneurons, it affects the tangential migration of cortical projection neurons. (c) 2006 Elsevier Inc. All rights reserved.