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Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons121755

Radziuk,  Darya V.
Helmuth Möhwald, Grenzflächen, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons121654

Möhwald,  Helmuth
Helmuth Möhwald, Grenzflächen, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Radziuk, D. V., & Möhwald, H. (2015). Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells. Physical Chemistry Chemical Physics, 17(33), 21072-21093. doi:10.1039/C4CP04946B.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0027-1329-F
Abstract
Single molecule surface enhanced Raman scattering (SM-SERS) is a highly local effect occurring at sharp edges,} interparticle junctions and crevices or other geometries with a sharp nanoroughness of plasmonic nanostructures ({"}hot spots{"}). The emission of an individual molecule at SM-SERS conditions depends on the local enhancement field of the hot spots{,} as well as the binding affinity and positioning at a hot spot region. In this regard{,} the stability of near-field nano-optics at hot spots is critical{,} particularly in a biological milieu. In this perspective review{,} we address recent advances in the experimental and theoretical approaches for the successful development of SM-SERS. Significant progress in the understanding of the interaction between the excitation electromagnetic field and the surface plasmon modes at the metallic or metallic/dielectric interface of various curvatures are described. New knowledge on methodological strategies for positioning the analytes for SM-SERS and Raman-assisted SERS or the SERS imaging of live cells has been acquired and displayed. In the framework of the extensive development of SM-SERS as an advancing diagnostic analytical technique{,} the real-time SERS chemical imaging of intracellular compartments and tracing of individual analytes has been achieved. In this context{, we highlight the tremendous potential of SERS chemical imaging as a future prospect in SERS and SM-SERS for the prediction and diagnosis of diseases.