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Journal Article

Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons58380

Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Supplementary Material (public)

ol0508781si20050421_064444.pdf
(Supplementary material), 181KB

ol0508781si20050421_064515.pdf
(Supplementary material), 2MB

Citation

Ghalit, N., Poot, A. J., Fürstner, A., Rijkers, D. T. S., & Liskamp, R. M. J. (2005). Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z. Organic Letters, 7(14), 2961-2964. doi:10.1021/ol0508781.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0025-AA6C-A
Abstract
Ring-closing alkyne metathesis toward the synthesis of the alkyne-brigded A-, B-, C-, and (D)E-ring mimics of the peptide antibiotic nisin Z is described. We have successfully synthesized alkyne-bridged cyclic peptides containing 4−7 amino acid residues in yields ranging from 18 to 82%.